Author/Authors :
ZAHER, HESHAM Cairo University - Faculty of Medicine - Department of Dermatology, Egypt , SAYED, SAFINAZ Cairo University - Faculty of Medicine - Department of Histology, Egypt , BASSIOUNY, DALIA Cairo University - Faculty of Medicine - Department of Dermatology, Egypt , ABD EL-HAY, RANIA Cairo University - Faculty of Medicine - Department of Dermatology, Egypt , SAMIR, NESREEN Cairo University - Faculty of Medicine - Department of Dermatology, Egypt , RAGAB, NANEES Cairo University - Faculty of Medicine - Department of Dermatology, Egypt
Abstract :
Background: Acquired Melanocytic Nevi (AMN) have been reported to undergo morphological and dermoscopic changes following exposure to NB-UVB radiation.Objectives: To study the immunohistochemical changes in AMN exposed to NB-UVB radiation.Patients and Methods: 40 patients diagnosed with different dermatological conditions were enrolled in the study. Three sessions of suberythemogenic NB-UVB per week were delivered for a total of 30 sessions. For each patient a minimum of 2 nevi were selected. One nevus was surgically removed prior to sessions as control. At the end of the irradiation cycle another nevus was surgically removed. Immunohistochemical assessment of Ki67 (marker of proliferation) and Melan A (marker of melanogenesis) were done for the biopsy specimens.Results: The mean value of Ki67 has increased as well as the mean value of MA but it was not statistically significant. Mean Ki67 change was 0.13±1.4 (p=0.621). Mean MA change was 0.29±.68 (p=0.350).Conclusion: Suberythemogenic doses of NB-UVB did not induce a statistically significant change in Ki67 (proliferation marker) and Melan A (melanogenesis related protein). These findings support the safety of suberythemogenic NB-UVB phototherapy.
