Dobutamine Stress Tissue Doppler for Evaluation of Myocardial Ischemia

Objective: The rule of dobutamine stress-tissue Doppler in detection of myocardial ischemia.Material and Methods: 35 patients with known or suspected CAD were divided into: Ischemic group (15pts) with coronary stenosis ≥ 50%, normal echocardiography and control (20 patients) with normal coronary angiography and echocardiography. Dobutamine stress-Tissue Doppler was applied to basal and mid myocardial segments with measuring S, E and A velocities at rest and peak stress.Results: At rest: No statistical difference in S between ischemic group and control (7.9±1.4 vs 9±2cm/sec, respectively, P: NS). E was statistically lower in ischemic group than control (8.7±2.1 vs 11.8±3.2cm/sec, respectively, p 0.05).With Stress: The increase in S and E were statistically lower in ischemic segments than control (S: 15.4±2.4 vs 23.5±4.4 cm/sec and E : 15.2±3.7 vs 23.3±4.9cm/sec, respectively, p 0.05).No difference between both groups regarding A velocities at rest or peak stress.Cut-off values for ischemia: ∆S ≤115% and ∆E ≤104% (∆ the increase from rest to peak stress) with sensitivity 83%, 79% and specificity 84%, 79% respectively.Conclusion: TDI provided objective quantitative information about myocardial ischemia.