Effects of Aerobic Exercise Plus Weight Reduction Program on Visfatin Hormone in Diabetic and Non-Diabetic Obese Men

Aim of the Study: Was to evaluate the effects of aerobic exercise Weight reduction Programs on serum visfatin hormone in diabetic and non-diabetic obese men.Design: This study was conducted from October 2013 to December 2014 at October 6th University hospital.Patients: This study conducted on forty diabetic and non- diabetic obese men (BMI, 30-39.9 Kg/m²) men aged 35 to 50 years for 3 months. Intervention: The 40 men were randomly assigned to two groups equal in number. Group 1: (Diabetic obese; n=20), and Group 2: (Non-diabetic obese; n=20). Both groups received weight reduction Programs (healthy lifestyle changes and diet-induced weight loss (1300-1500 Kcal/day) plusaerobic exercise program on walking treadmill for 50 minutes, 3 times/week for 3 months.Main Outcomes Measures: Weight, body mass index (BMI), waist circumference (WC), fasting blood glucose (FBG), serum insulin, HOMA-IR, Hb Ale and serum visfatin were measured.Results: After 3 months, Men in group 1 demonstrated high significant statistically differences in the mean values of weight (p=0.001), BMI (p=0.001), Waist circumference (p=0.001), FBS (/ =0.001, insulin (p=0.001), HOMA-IR (p=0.001), Hb Ale (p=0.001) and serum visfatin (p=0.001). Men in group 2 showed a highly significant reductions in weight (p=0.001), BMI (p=0.001), Waist circumference (p=0.001), WHR (p=0.001), and visfatin (p=0.001). FBG, serum insulin, and HOMA-IR showed significant reduction with (p=0.01), (p=0.01) p=0.01) respectively, but Hb Ale showed non-significant decrease with (p=0.1).Conclusions: Weight reduction program in the form of low-caloric diet, and exercise training improved all anthropo-metric measurements (weight, BMI, and WC), serum insulin, HOMA-IR and serum vesfatin in both diabetic and non-diabetic Obese Men