Author/Authors :
Panah Khahi, Mahdi tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesiology, تهران, ايران , Marashi, Shaqayeq tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesiology, تهران, ايران , Khajavi, Mohammad Reza tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesiology, تهران, ايران , Najafi, Atabak tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesiology, تهران, ايران , Yaghooti, Amirabbas tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesiology, تهران, ايران , Imani, Farsad tehran university of medical sciences tums - Faculty of Medicine - Department of Anesthesiology, تهران, ايران
Abstract :
Background: Gabapentin is an anticonvulsant that has postoperative analgesic effectsbut there are limited studies on its postoperative administration.Objectives: The present study was conducted to evaluate the effect of the postoperativeoral gabapentin on pain and morphine consumption.Patients and Methods: In a double blind, randomized study, 64 patients undergoinginternal fixation of tibia under spinal anesthesia were randomly assigned to receiveoral gabapentin or placebo immediately after the surgery. Pain scores were recorded attime points of 2, 12 and 24 hours postoperatively using visual analog scale (VAS). Timeduration from the end of surgery until morphine administration and total morphinerequirement in the first 24 hours were recorded.Results: The estimated duration of surgeries was 120-150 minutes. VAS score was not significantlydifferent between the two groups at 2, 12 and 24 hours after surgery. There wasno significant morphine consumption difference between the groups.Conclusions: Our study showed no significant analgesic efficacy of oral gabapentin 300mg immediately after tibia internal fixation surgery under spinal anesthesia at timepoints of 2, 12 and 24 hours postoperatively.
