Author/Authors :
Jabbary Moghaddam, Morteza shahid beheshti university of medical sciences - Anesthesiology Research Center, تهران, ايران , Ommi, Davood shahid beheshti university of medical sciences - Anesthesiology Research Center, تهران, ايران , Mirkheshti, Alireza shahid beheshti university of medical sciences - Anesthesiology Research Center, تهران, ايران , Dabbagh, Ali shahid beheshti university of medical sciences - Anesthesiology Research Center, تهران, ايران , Memary, Elham shahid beheshti university of medical sciences - Anesthesiology Research Center, تهران, ايران , Sadeghi, Afsaneh shahid beheshti university of medical sciences - Anesthesiology Research Center, تهران, ايران , Yaseri, Mehdi tehran university of medical sciences tums - Department of Epidemiology and Biostatistics, تهران, ايران
Abstract :
Background: Opium is a highly addictive agent and the most common narcotic often misused in Iran. The pharmacokinetic of anesthetic drugs in patients with opium addiction is one of the great challenges for anesthesiologists. Hemodynamic instability and postoperative side effects are of these challenges which should be managed correctly. Objectives: In this study we aimed to assess the effects of clonidine upon post anesthesia shivering and recovery time in patients with and without opium addiction after general anesthesia to decrease the subsequent complications related to the shivering and elon- gation of recovery time. Patients and Methods: In a randomized clinical trial, 160 patients candidates for elec- tive leg fracture operations under general anesthesia were studied in four groups of 40 patients: Group 1 (placebo 1) were patients without addiction who got placebo 90 minutes before the operation. Group 2 (placebo 2) were patients with opium addiction which received placebo as group 1. Group 3 (Clonidine 1) patients without addiction who got clonidine 90 minutes before the operation and group 4 (Clonidine 2) who were opium addicted ones which received clonidine as premedication. Results: None of the patients with and without addiction in clonidine groups had shiv- ering after the operation but in placebo groups shivering was observed and the difference between clonidine and placebo groups was statistically significant (P 0.01). Recovery time in clonidine groups of patients with and without addiction was less than placebo ones (both P 0.01) which the magnitude of difference was higher in opium addicted than non-addicted patients (P = 0.04) Conclusions: Premedication with clonidine in patients with and without opium addiction can be effective to decrease the incidence of shivering and recovery time after operation.
