Gonadotrophins and Testosterone Serum Levels before and after LOD in Clomiphene Citrate Resistant Women with Polycystic Ovarian Syndrome: A Criteria for Success?

Objective: To determine the effect and impact of Laparoscopic Ovarian Drilling (LOD) on serum gonadotrophins and testosterone levels in Clomiphene Citrate (CC) resistant women with Polycystic Ovary Syndrome (PCOS). Could serum gonadotrophins and testosterone determine the response to LOD?Study Design: Prospective study.Patients and Methods: A clinical study was conducted on 60 clomiphene-resistant women with PCOS who were scheduled for LOD. Serum gonadotrophins and testosterone were measured before and a month after LOD. The results were correlated with outcome of treatment.Results: There was highly significant decrease in serum LH and Testosterone levels after LOD for all patients than before the procedure. There was highly significant increase in serum FSH levels after LOD in patients with PCOS. Serum LH levels were significantly higher for the favourable patients than the unfavourable patients before LOD.Conclusion: The data could contribute greatly to our understanding about the resumption of menstrual cyclicity and fertility after the commonly used ovarian surgery. Measuring serum hormone levels for women with anovulatory PCOS undergoing LOD may provide a useful tool in evaluating the outcome of LOD.