Author/Authors :
AHMED, WALID Cairo University - Faculty of Medicine - Department of Critical Care Medicine, Egypt , SAMY, WAEL Cairo University - Faculty of Medicine - Department of Critical Care Medicine, Egypt , TAYEH, OSAMA Cairo University - Faculty of Medicine - Department of Critical Care Medicine, Egypt , BEHAIRY, NOHA Cairo University - Faculty of Medicine - Department of Radiology, Egypt , EL-FATTAH, ALIA ABD Cairo University - Faculty of Medicine - Department of Critical Care Medicine, Egypt
Abstract :
Background: Left ventricular dyssynchrony plays an important role in predicting response to Cardiac Resynchronization Therapy (CRT).Methods: Thirty patients underwent CRT implantation. Assessment of Left Ventricular (LV) dyssynchrony was done through Gated Spect LV phase analysis.Results: Thirty patients received CRT (mean age 58.7±9.0, 24 males). CRT implantation had a favorable prognosis on cardiac functions (LVEF pre-implantation: 26.8±4.7% versus 29.1±6.4% post-implantation; p=0.002). Reverse LV remod-eling ( ≥15%) was documented in 19 patients. LV dyssynchrony parameters were correlated to LV reverse remodeling. Applying ROC curve for LV phase analysis showed that a cutoff 152º for histogram bandwidth had a sensitivity of 72.7% and specificity of 63.2% for predicting CRT non-response status. Also, a cutoff 54º for histogram standard deviation had a sensitivity of 81.8% and specificity of 63.2%.Conclusion: Responders of CRT showed improved LV dyssynchrony profiles. Utilizing Gated SPECT LV analysis could provide predictors for CRT non-response.
