Clinicopathological Spectrum of Prostatic Adenocarcinoma in 60 Patients

Background: Prostatic adenocarcinoma represents the second most common malignant tumor found in men over 65. It constitutes a source of morbidity and mortality.Methods: Haematoxylin and Eosin-stained-slides of sixty archival formalin fixed paraffin-embedded, routinely processed cases (30 cases as TUR-P biopsies, 26 cases as radical prostatectomy specimens and 4 cases as open prostatectomy specimens) were retrospectively and randomly collected from the Department of Pathology, Kasr El-Aini Hospital, Cairo University.Results: Seventy percent of patients aged above 60 years (the mean age was 67.38). Twenty-five patients (41.7%) had preoperative serum PSA level more than 10 up to 20ng/ml. Histologically, the acinar pattern was the most prevalent (29%). The majority (56.7%) had high-grade tumors. Perineural invasion was detected in 22 cases while 11 showed positive capsular invasion. In the 26 radical prostatectomy cases, the disease was confined to the gland (pT2) in 18 patients (69.3%) however; the remaining eight patients (30.7%) were staged as pT3.Conclusion: Serum PSA level does not significantly correlate with pathological features of prostatic adenocarcinoma. On the contrary, perineural invasion in radical prostatectomy is strongly associated with tumor grade and stage.