Magnesium Sulfate Versus Diazepam Infusion in Eclampsia

Abstract: The anticonvulsant has key role in management of eclampsia but the choice is still controversial.Objectives: To compare the efficacy of magnesium sulfate and diazepam infusion as good anticonvulsant.Study Design The study was conducted at Obst/Gynae Unit –II, Punjab Medical College, DHQ Civil Hospital, Faisalabad from 1st May, 2007 To 30th December,2007.Material and Methods: There were total 3506 deliveries in 8 months among 45 cases of antenatal eclampsia were selected. The cases of postpartum eclampsia, gestational age less than 28 weeks, and dead fetuses were excluded. 25 patients were allocated Mgso4 and 20 patients treated with Diazepam infusion regardless of prior therapy. The dosage of both was monitored clinically. Morbidity was defined in terms of maternal and fetal measures.Results: MGSO4 was the better anticonvulsant than diazepam infusion in terms of total morbidity, the value (P 0.05), recurrence of fits (16% versus 30%), maternal deaths (Null versus 5%), respiratory depression (Null versus 10%). Mgso4 was associated with better outcomes in terms of total fetal morbidity (28% versus 90%) and perinatal deaths (4% versus 15%) than diazepam the value (P 0.05). Fewer babies in Mgso4 group had low apgore score at 1 minute (12% versus 25%), at 5 minute (Null l% versus 10%), required less intubations (8% versus 25%) and required less admission in special care unit (4% VS 15%) than diazepam group