A Cross Sectional Study to Compare the Specificity of Creatine Kinase – MB (CK – MB), Cardiac Troponin T (CTnT) and Cardiac Troponin I (CTnI) to Rule in Acute Myocardial Infarction

Background: Distinguishing whether a patient presenting with chest pain has acute myocardial infarction (AMI) or non-cardiac problem is at times difficult. Ruling out AMI requires a test with high diagnostic sensitivity, whereas ruling in AMI requires a test with high diagnostic specificity. This study was planned with the aims and objectives to find out the better marker for the identification of acute myocardial infarction. Methods: The study population consisted of 70 patients. Patients from both sexes, with clinical history of typical chest pain for more than 30 minutes in duration with evidence of acute changes of myocardial infarction on ECG were included in the study. This study was conducted to compare the sensitivity of creatine kinase – MB (CK – MB), cardiac troponin T (CTnT) and cardiac troponin I (CTnI) for detection of AMI. Data analysis was performed with Statistical Package for Social Sciences 11.5 (SPSS 11.5). Results: The sensitivity of CK – MB was 100% and 17.78% as compared to CTnT and CTnI respectively. The sensitivity of CTnT was 46.67% and 38.10% as compared to CK-MB and CTnI respectively while the sensitivity of CTnI was100% as compared to both CK – MB and CTnT. Conclusion: It is concluded that CTnI is the preferred, dependable and cost effective serum markers for detection of AMI as compared to CTnT and CKMB.