VARIATION IN REGIONAL DISTRIBUTION OF MULTIPLE SCLEROSIS PLAQUES IN PAKISTANI AND CANADADIAN NATION

Background and Purpose: To determine retrospectively the variation in regional involvement of brain among established cases of MS Canadian and Pakistani nation. We also analyzed parahippocampal gyrus lesions with further characterization according to grey white matter distribution. Methods: Sixty patients presenting clinically with multiple sclerosis were included as two groups of thirty each from Canadian and Pakistani nation respecttively. Imaging was performed on 1.5 T MR system acquiring T1W, T2W, Proton density, FLAIR and T1W post gadolinium sequences. Lesions were counted and classified according to anatomic regions paraventricular, temporal lobe and juxtacortical. The juxtacortical involvement of parahippocampal region considering brain parenchymal involvement were classified. King Edward Medical University, Lahore Results: Canadians haved more disease load as compare to Pakistani nation. Mean age of the patients are relatively younger in Canadians however anatomical lesional distribution in temporal lobe, paraventricular and parahippocampal region more or less same. Conclusion: Multiple sclerosis is more common among Canadian however its lesional anatomical distribution including parahippocampal region had no significant variation.