Author/Authors :
Dey, Soumit Scientific Clinical Research Laboratory - Department of Pathology (Histopathology), India , Chaudhury, Mrinal K. Scientific Clinical Research Laboratory - Department of Pathology (Histopathology), India , Basu, Samar K. Scientific Clinical Research Laboratory - Department of Pathology (Histopathology), India , Chaudhury, Kaberi Scientific Clinical Research Laboratory - Department of Pathology (Histopathology), India , Chatterjee, Amitava Scientific Clinical Research Laboratory - Department of Pathology (Histopathology), India , Manna, Asim K. Scientific Clinical Research Laboratory - Department of Pathology (Histopathology), India , Dutta, Subir K. Scientific Clinical Research Laboratory - Department of Pathology (Histopathology), India
Abstract :
A 30-year-old female presented with headache and gait disturbance which were gradually progressive for the past three months. On T1 weighted magnetic resonance imaging (MRI), it appeared to be a 35mm x 25mm x 20mm hyperintense mass in the left cer-ebellar hemisphere encroaching on the vermis and causing compression of the fourth ventricle (Figure 1). A tiny biopsy, reported as medulloblastoma elsewhere, was followed by incomplete removal of the tumor and the patient failed to turn up for a follow-up. Six months later, the symptoms reappeared and a rebiopsy was taken.The rebiopsy specimen showed a biphasic appearance with areas of lipidized vacuolated cells and neurocytic cells with small round to oval nuclei and scant clear cytoplasm in H E- stained sections at 100x and 400x magnifications, respectively (Figures 2, 3). Immmunohistochemistry revealed positivity for neuron- specific enolase and synaptophysin in neurocytic cells and adipocyte-like cells and a low MIB-1 index of 3%.
