Author/Authors :
Geramizadeh, Bita shiraz university of medical sciences - Transplant Research Center - Department of Pathology, ايران , Nikeghbalian, Saman shiraz university of medical sciences - Transplant Research Center - Transplant Ward, ايران , Kazemi, Kurosh shiraz university of medical sciences - Transplant Ward, ايران , Shamsaifar, Alireza shiraz university of medical sciences - Transplant Ward, ايران , Bahador, Ali shiraz university of medical sciences - Transplant Ward, ايران , Salahi, Heshmatollah shiraz university of medical sciences - Transplant Ward, ايران , Malekhosseini, Ali shiraz university of medical sciences - Transplant Ward, ايران , Kashtkar Jahromi, Marzieh shiraz university of medical sciences - Department of Pathology, ايران , Bakhshai Dehkordi, Ali shiraz university of medical sciences - Department of Pathology, ايران
Abstract :
Background: This study was conducted to determine the impact of hepatitis B virus (HBV) as a cause of hepatocellular carcinoma (HCC) in a single liver transplant center in Iran. Methods: Afe included all hepatectomy specimens from patients with HBV-related cirrhosis who underwent transplants from May 1993 until January 2012 in this study. From these, we determined the number that had HBV-induced HCC. Nested PCR results were used to determine the HBV genotype from sections of the hepatectomy pathology specimens. Results: During this time period there were 1361 cirrhotic livers transplanted in our center. Of these, 249 were attributed to HBV cirrhosis. Overall, HCC was detected in 40 (2.9%) subjects, of which 29 (1.2%) had HBV-related HCC. Genotype D was only genotype observed in all HBV subjects. Conclusion: The results revealed that although HBV-related cirrhosis was the most frequent single cause for liver transplant, the frequency of HBV-induced HCC was very low among transplant recipients. Out of 1361 transplant recipients, only 29 (2.1%) were diagnosed with HBVrelated HCC. All HBV subjects had genotype D.
