Author/Authors :
Vand Rajabpour, Fatemeh tehran university of medical sciences tums - School of Medicine - Department of Medical Genetics, تهران, ايران , Raoofian, Reza tehran university of medical sciences tums - School of Medicine - Department of Medical Genetics, تهران, ايران , Habibi, Laleh tehran university of medical sciences tums - School of Medicine - Department of Medical Genetics, تهران, ايران , Akrami, Seyed Mohammad tehran university of medical sciences tums - School of Medicine - Department of Medical Genetics, تهران, ايران , Tabrizi, Mina University of Medical Sciences - School of Medicine - Department of Medical Genetics, ايران
Abstract :
Forty-five percent of the human genome is composed of Transposable Elements (TEs); therefore, TEs have had an undisputed impact on evolution of the most evolved creature by a very simple mechanism of action. Scientists have been studying this simple mechanism of action and are currently using it to develop efficient and safe gene delivery systems especially for treatment of diseases. TEs have also been used safely in generating induced Pluripotent Stem Cells (iPSC) for regenerative medicine, which opens the door to a world of pos- sibilities in our approach in trying to wrestle with many challenges in medicine. The PiggyBac (PB) system has yielded more success in generation of induced pluripotent stem cells in regenerative medicine, and the Sleeping Beauty (SB) has been more successful in Gene Therapy. Recent advances are indicative of more good news to come regarding the potential heights of successes achievable by the use of the TE-based systems.
Keywords :
Gene therapy , genetic transposition , induced pluripotent stem cell (iPSC) , transposable elements (TEs) , transposable ele , ment based vectors (TEV)
