Author/Authors :
Sharafi, Farshid tehran university of medical sciences tums - Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, تهران, ايران , Najafi, Baharak tehran university of medical sciences tums - Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, تهران, ايران , Fakhrzadeh, Hossein tehran university of medical sciences tums - Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, تهران, ايران , Noroozian, Maryam tehran university of medical sciences tums - School of Medicine - Geriatric Education Group, تهران, ايران , Naderimagham, Shohreh iran university of medical sciences - Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Sciences Institute, ايران , Philp, Ian Hull and East Yorkshire NHS HospitalsTrust, UK , Arzaghi, Masood tehran university of medical sciences tums - Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, تهران, ايران , Alizadeh, Mahtab tehran university of medical sciences tums - Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, تهران, ايران , Shoaee, Shervan tehran university of medical sciences tums - Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, تهران, ايران , Hassannia, Tahereh tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران , Sheidaei, Ali shahid beheshti university of medical sciences - Faculty of Paramedical Sciences - Department of Biostatistics, تهران, ايران , Sheidaei, Ali tehran university of medical sciences tums - Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Science Institute, تهران, ايران , Moradi-Lakeh, Maziar iran university of medical sciences - Community Medicine Department, ايران , Farzadfar, Farshad tehran university of medical sciences tums - Non-Communicable Disease Research Center, Endocrinology and Metabolism Population Science Institute, Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Researsh Institute, تهران, ايران , Larijani, Bagher tehran university of medical sciences tums - Endocrinology and Metabolism Research Center, تهران, ايران
Abstract :
BACKGROUND: Dementia is a disabling syndrome, which generally affects aged population more than any other age group. This syndrome has a growing prevalence and incidence worldwide. The prevalence and burden of this group of diseases in Iran have not been estimated in a community-based study yet. This paper aims to explain the systematic approach, data sources, research methodology, and statistical analysis that will be used to quantify the prevalence and burden of dementia at national and sub-national levels. METHODS: This is the protocol of a secondary data study that explains the design and method of conducting the study. We will use several sources of data that will include a systematic review of articles and gray literature which have reported the prevalence or incidence of dementia and its uncertainty at national and sub-national levels in Iran, in addition to data about dementia-specific drug sales per each year at provincial levels, as well as data extracted from 23 million health insurance prescriptions over 8 years and some data from medical documents of Iranian Alzheimer’s Association members. The technical groups of National and Sub-national Burden of Disease will collect some covariate data, such as age and sex structure of population, urbanization status, mean years of schooling, plasma cholesterol, fasting plasma glucose, and systolic and diastolic blood pressure at provincial levels which will be used in our models. Two statistical models, namely spatio-temporal and hierarchical autoregressive models, will be used for interpolation and extrapolation of missing data. CONCLUSION: It seems that the study of national and sub-national burden of dementia could provide more accurate estimation of prevalence and burden of dementia in Iran with an acceptable level of uncertainty than the previous studies.
