Title of article :
Synthesis and molecular docking of novel N-((2-chloroquinolin-3-yl) methylene)-4-methylbenzenamine derivatives as anti-HIV-1 reverse transcriptase inhibitors
Author/Authors :
Fazlinezhad ، Maassoumeh Department of Chemistry - Payame Noor University , Nakhaei ، Ahmad Young Researchers and Elite Club - Islamic Azad University, Mashhad Branch , Eshghi ، Hossein Chemistry Department - Faculty of Science - Ferdowsi University of Mashhad , Saadatmandzadeh ، Mohammad Chemistry Department - Faculty of Science - Ferdowsi University of Mashhad
Abstract :
In this research work, a proficient method has been developed for the preparation of novel N-((2-chloroquinolin-3-yl) methylene)-4-methylbenzenamine derivatives from 2chloroquinoline3carbaldehyde derivatives and ptoluidine in ethanol as solvent and using catalytic amount of acetic acid under reflux conditions to obtain desired products in good yields. The identification of all the synthesized compounds was confirmed by melting point, FTIR, 1H NMR, and 13C NMR. Also, in present work all the synthesized compounds were evaluated for their molecular docking as anti-HIV-1 reverse transcriptase inhibitors using GOLD 5.2. software. The result of molecular docking showed that all the compounds established ‘π–π’ interactions with side chain of amino acid.
Keywords :
N , ((2 , chloroquinolin , 3 , yl) methylene) , 4 , methylbenzenamine , Molecular docking , p , toluidine , 2 , chloroquinoline , 3 , carbaldehyde , anti , HIV , vilsmeier , haack reagent
Journal title :
Eurasian Chemical Communications
Journal title :
Eurasian Chemical Communications
