Title of article :
Long-Term Administration of Oral Low-Dose Topoisomerase II Inhibitors, MST16 and VP-16, for Refractory or Relapsed Non-Hodgkins Lymphoma
Author/Authors :
Kakishita، Eizo نويسنده , , Okamoto، Takahiro نويسنده , , Nishimura، Yasuo نويسنده , , Yamada، Shinji نويسنده , , Yamada، Shu نويسنده , , Itoh، Tohru نويسنده , , Mori، Ako نويسنده , , Saheki، Kaname نويسنده , , Okada، Masaya نويسنده , , Takatsuka، Hiroyuki نويسنده , , Wada، Hiroshi نويسنده , , Tamura، Amane نويسنده , , Fujimori، Yoshihiro نويسنده ,
Abstract :
It is known that the topoisomerase II inhibitors, MST-16 (sobuzoxane) and VP-16 (etoposide), are effective for the treatment of lymphoma. Five patients with refractory or relapsed non-Hodgkinʹs lymphoma (NHL) were treated with a combination of oral MST-16 and VP-16 over a long period. Two patients had severely refractory NHL. The remaining 3 patients could not be treated with intensive chemotherapy because of severe organ dysfunction or a poor hematopoietic reserve. All 5 are alive and well after MST-16 and VP-16 treatment. MST-16 and VP-16 are effective for NHL when intensive chemotherapy is ineffective or contraindicated.
