The Effects of the Grape Seed Extract on Streptococcus mutans and Candida albicans: An In Vitro Study

Background: Oral pathogens can affect a large population and the general health of individuals. Based on the evidence, the grape seed extract (GSE) contains herbal compounds that have the ability to suppress oral pathogens associated with caries and fungal diseases. In this regard, the current study aimed at evaluating the effect of GSE on Streptococcus mutans and Candida albicans. Methods: The grape (Vitis vinifera L.) seed was used in this in-vitro experimental study. After the preparation of methanolic GSE, its effect on S. mutans and C. albicans was assessed at 0.25-256 mg/mL concentrations. Then, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined by macro broth dilution methods. Finally, data were analyzed by SPSS, version 20. Results: The results showed that GSE inhibits the growth of S. mutans and C. albicans. In addition, the MIC and MBC of the extract against S. mutans and C. albicans were 2 and 8 mg/mL, as well as 32 and 64 mg/mL, respectively. Conclusions: In general, GSE had a significant antimicrobial effect on S. mutans, while it only affected C. albicans at high concentrations.