STATUS OF ANTIOXIDANT AND LIVER FUNCTION IN TYPE-2 DIABETIC PATIENTS ATTENDING NEPALGUNJ MEDICAL COLLEGE

Objective: Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by hyperglycemia due to defects in insulin secretion, insulin action or both. This study aims to investigate the status of antioxidants and liver function in type-2 diabetic patients among patients attending OPD of Nepalgunj Medical College, Banke, Nepal. Methods: A total of 280 samples were recruited to evaluate aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), glutathione (GSH), and superoxide dismutase (SOD). Determination of all biochemical parameters were carried out using Kit Methods. Results: AST level was elevated in maximum number of patients, 64 (36.57%) out of175 males and 59 (56.19%) out of105 females followed by ALT elevation in females and ALP elevation in males, 50 (47.61%) out of 105 and 57(32.57%) out of 175 respectively. Conclusion: Antioxidants LFTs were found to be statistically significant when compared with healthy controls.