Effect of L-Arginine on glomerular endotheliosis improvement in preeclampsia

Background: Preeclampsia is the leading cause of morbidity and mortality in pregnant women and the fetus. In preeclampsia, glomerular endotheliosis occurs due to endothelium dysfunction in the kidney. Supplementation with L-Arginine is postulated to improve glomerular endotheliosis. The aim of this study is to investigate the effect of L-Arginine on improving glomerular endotheliosis in an animal model of preeclampsia. Method: This is an analytical experiment research which was conducted in November 2016 to January 2017 in Biomedical Laboratory Faculty of Veterinary Medicine, University of Airlangga, Surabaya. Thirty pregnant mice (Mus musculus) were used in this research. The mice were divided equally into three groups, normal pregnant mice (K1), pregnant mice model of preeclampsia (K2), and preeclampsia pregnant mice treated with L-Arginine (K3). The kidneys were then obtained surgically and examined with immunohistochemistry examination. Data were analyzed by using one-way ANOVA and Post-hoc test. Results: The mean score of glomerular endotheliosis were 0.44 ± 0.42 for K1, 1.34±0 for K2, and 0.62±0.45 for K3. There was a significant difference between K1 and K2 (p=0.0000), and also between K2 and K3 (p=0,000). Conclusion: L-Arginine is effective on improving glomerular entoheliosis in a mouse model of preeclampsia.