Author/Authors :
asl, s.s. hamadan university of medical sciences, ايران , falahati, p. tehran university of medical sciences tums, تهران, ايران , riz, n.s. tehran university of medical sciences tums, تهران, ايران , molavi, n. tehran university of medical sciences tums, تهران, ايران , esmaeili, f. tehran university of medical sciences tums, تهران, ايران , azimi, z. tehran university of medical sciences tums, تهران, ايران , sajadi, f. tehran university of medical sciences tums, تهران, ايران , hayat, p. tehran university of medical sciences tums, تهران, ايران , samzadeh-kermani, a. zabol university, زابل, ايران , mehdizadeh, m. tehran university of medical sciences tums, تهران, ايران
Abstract :
Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes apoptosis in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMAinduced apoptosis. Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0,5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method. Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMAinduced apoptosis. Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity.
Keywords :
4 , methylenedioxyamphetamine , Acetylcysteine , Apoptosis , N , methyl , 3
