Author/Authors :
Moghadami, Malihe ferdowsi university of mashhad - Faculty of Science, Roshd Center, Applied Research and Production Center of Lab Animals, Radman Pajoohan Jam Company - Department of Biology, مشهد, ايران , Moghimi, Ali ferdowsi university of mashhad - Faculty of Science, Applied Research Center for Neurofeedback and Neurobehavioral Sciences (Aren) - Department of Biology, مشهد, ايران , Ahangar, Emad ferdowsi university of mashhad - Roshd Center, Applied Research and Production Center of Lab Animals, Radman Pajoohan Jam Company, مشهد, ايران , Ahangar, Emad Islamic Azad University, Kashmar Branch - Department of Civil, ايران , Jalal, Razieh ferdowsi university of mashhad - Faculty of Science - Department of Chemistry, مشهد, ايران , Rassouli, Morteza Behnam ferdowsi university of mashhad - Faculty of Science - Department of Biology, مشهد, ايران , Mahdavi Shahri, Naser ferdowsi university of mashhad - Faculty of Science - Department of Biology, مشهد, ايران
Abstract :
Anxiety symptoms have been reported to be present in many patients with diabetes mellitus. However, little is known about the effects of hyperglycemia in critical periods of the central nervous system development. We assessed locomotive, exploratory, and anxiety behaviors in adult rats that remained from infantile repeated hyperglycemia by the open field and elevated plus maze tests. Our findings showed significant hypo activity, reduced locomotive/exploratory activities, increased fear related behaviors, and anxiety state between hyperglycemic and control adult males and the same differences were observed among females. In addition, no significant behavioral alterations between male and female animals were observed. This study determined that repeated increments in daily blood sugar levels in newborns may affect neuronal functions and provide behavioral abnormalities in adults.
Keywords :
Anxiety , Elevated plus maze , Exploratory , Hyperglycemia , Locomotive , Open field
