Title of article :
Ecstasy-induced caspase expression alters following ginger treatment
Author/Authors :
asl, s.s. hamadan university of medical sciences, ايران , pourheydar, b. urmia university of medical sciences, ايران , dabaghian, f. research institute for islamic and complementary medicine, tehran university of medical sciences, ايران , nezhadi, a. aja university of medical sciences, ايران , roointan, a. hamadan university of medical sciences, ايران , mehdizadeh, m. tehran university of medical sciences tums, تهران, ايران
Abstract :
Introduction: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. Methods: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. Results: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p 0.001). Ginger administration however, appeared to significantly decrease the same (p 0.001). Discussion: Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity.
Keywords :
Apoptosis , Caspase , Ginger , MDMA
Journal title :
Basic and Clinical Neuroscience
Journal title :
Basic and Clinical Neuroscience
