Blighted ovum: Roles of human leukocyte antigen-E and natural killer cells

Background: The failure of premature conception product is a specific problem for pregnant women. Blighted Ovum occurred in 37.5% of early pregnancy failure. About 15% of Blighted Ovum is caused by disorders of the immune system. Human Leukocyte Antigen-E and Natural Killer Cell are supposed to be the main factors of this pathomechanism. Objective: To determine the expression of Human Leukocyte Antigen-E and Natural Killer Cell cells in the Blighted Ovum and normal pregnancy. Methods: Observational analytic with cross sectional approach. Thirty-two samples were divided into two groups: 16 samples of Blighted Ovum group and 16 samples of normal pregnancy group. uman Leukocyte Antigen-E and Natural Killer Cell cells in trophoblast of both groups were examined with immunohistochemical methods and statistical analysis that was done by t-test. Results: The mean of expression of Human Leukocyte Antigen-E in the group of Blighted Ovum are 75.15±6:30, normal pregnancy are 83.13±11:26, p-value=0:02 (P 0.05). The mean of expression of NK cells in the group of a normal pregnancy is 79.72±6.63, while the mean of expression of NK cells in Blighted Ovum is 93.88±14.08, p-value=0.00 (P 0.05). Conclusion: The expression of HLA-E was lower, and NK cells were higher in Blighted Ovum when compared with normal pregnancy.