Author/Authors :
niti susila, k udayana university - faculty of medicine, sanglah general hospital - department of ophthalmology, Indonesia , mahayani, nm udayana university - faculty of medicine, sanglah general hospital - department of ophthalmology, Indonesia , triningrat, aa udayana university - faculty of medicine, sanglah general hospital - department of ophthalmology, Indonesia , widiana, ig udayana university - faculty of medicine,sanglah general hospital - department of internal medicine, Indonesia , djelantik, aa udayana university - faculty of medicine, sanglah general hospital - department of ophthalmology, Indonesia , jayanegara, wg udayana university - faculty of medicine, sanglah general hospital - department of ophthalmology, Indonesia
Abstract :
Background: The therapy for dry eye (DE) remains controversial. Some studies concluded that the ideal therapy for DE is based etiopathogenesis. Dry eye is caused by a decrease in antioxidant level; one of them is superoxide dismutase (SOD). This study assessed the correlation between SOD level and DE degree as therapy based on the etiopathogenesis of DE. Method: This study was a cross-sectional study in Sanglah eye clinic, in January until June 2016, with a total of 51 samples with DE. The samples were categorized based on DE degree, namely 0, 1, 2, 3, and 4 respectively. The SOD serum examination was performed on each group. Correlation between SOD level and DE degree was analyzed with Pearson correlation test. Results: This study obtained data on sex, age, history of diabetes mellitus, history of smoking, and history of ocular surgery from five groups of DE in homogeneity. There was a negative correlation between SOD level and DE degree (r = -0.373; p = 0.007). Conclusion: SOD level has a negative correlation with DE degree.
