Homeostatic system of sheep against the background of combined effects of pollutants and the use of therapeutic and preventive agents

Nowadays, increasing harmful effects of environmental factors and their intensifying influence go beyond biological adaptability of ecosystems to the changes in the environment and pose a direct threat to the life and health of animals and humans. In general, xenobiotics, especially dioxins, enter the environment in small amounts but possessing material and functional cumulation they can cause considerable harm to the body. Analysis of our study shows that the xenobiotics entering the body of animals even at low concentrations cause functional changes in the body. Thus, the administration of 2,3,7,8-TCDD at a dose of 1/400 LD50 (0.5 μg/kg of body weight) and T-2 toxin at a dose of 200 μg/kg of fodder weight into the body of sheep causes erythropenia, leukopenia, hemoglobinemia, and a decrease in the number of T- and B-lymphocytes. The experiments show that xenobiotics is affecting the liver tissue cause lysis of hepatocytes releasing liver enzymes such as alanine aminotransferase and aspartate aminotransferase into the blood. The increase in these enzymes in serum reflects not only the liver injuries but also the dysfunction of other organs. In addition, dioxin and T-2 toxin cause an increase in the level of malondialdehyde, which results from lipid peroxidation. The application of DAS-2 at a dose of 3 ml/h and bentonite at a dose of 2% of dry matter, succinic acid at a dose of 25 μg/kg of body weight, and bentonite at the above-mentioned dose has a positive effect on sheep in combined dioxin and T-2 toxin poisoning and is characterized by the normalization of hematological, biochemical indicators, the content of T- and B-lymphocytes, and a decrease in the malondialdehyde content.