Author/Authors :
Aref, Salah Mansoura University - Oncology Center, Mansoura Faculty of Medicine - Haematology unit, Clinical Pathology Department, Egypt , Elkhodary, Tawfik Mansoura University - Oncology Center, Mansoura Faculty of Medicine - Medical Oncology Unit, Egypt , Azmy, Emad Mansoura University - Oncology Center, Mansoura Faculty of Medicine - Clinical Hematology Unit, Egypt , Hakim, Hazem Mansoura University - Oncology Center, Mansoura Faculty of Medicine - Internal Medicine Department, Egypt , El Menshawy, Nadia Mansoura University - Oncology Center, Mansoura Faculty of Medicine - Hematology Unit, Clinical Pathology Department, Egypt , Ebrahim, Lamiaa Mansoura University - Oncology Center, Mansoura Faculty of Medicine - Hematology Unit, Clinical Pathology Department, Egypt
Abstract :
Background: Controversial results concerning the prognostic value of the Tregs cells percentage in peripheral blood of chronic lymphocytic leukemia (CLL) patients have been reported in the previous studies. Materials and Methods: This study aimed to estimate the prognostic relevance of Tregs cells in untreated CLL patients at diagnosis. Results: CLL patients showed significantly higher Tregs percentage and Tregs cell counts as compared that identified in healthy normal controls (p 0.01 for both). Furthermore, CLL patients with high LDH, β2 microglobulin levels, those positive for CD38% express significantly higher Tregs percentage as compared to those patients with normal LDH, β2 microglobulin levels and negative CD 38%. Also, the percentage of Tregs cells was significantly higher among CLL patients having autoimmune cytopenias. Conclusion: Tregs cells percentage is higher in CLL patients as compared to normal healthy controls and related to advanced stages as well as poor prognostic markers. Tregs manipulation may represent a future strategy for management of CLL patients.
