Evaluation of antifungal effect of silver nanoparticles against microsporum canis,trichophyton mentagrophytes and microsporum gypseum

Background: Dermatophytosis is the common cutaneous infections in humans and animals,which is caused by the keratinophylic fungus called dermatophytes. In recent years,drug-resistance in pathogenic fungi,including dermatophytes to the current antifungals have been increased. The aim of this study was to evaluate the antifungal efficacy of AgNPs against Microsporum canis,Trichophyton mentagrophytes,and Microsporum gypseum. Materials and Methods: The antifungal susceptibility of nano-silver particles compared with griseofulvin(GR). Its efficacy was investigated against three strains of dermatophytes by both agar dilutionand broth microdilution test (BMD). Results: The average minimum inhibitory concentration (MIC) Ag-NPs on M. canis,T. mentagrophytes and M. gypseum were 200,180 and170 μg.ml-1,respectively. Whereas these strains showed MIC of 25,100 and 50 μg.ml-1 for GR. Conclusions: Our finding indicated that the AgNPs was less active than GR but it had anti-dermatophytic effect.