One-pot synthesis of functionalized thiazolidine-4-ones from thiosemicarbazone derivatives and activated acetylenes in water as a green solvent

Some 2-iminothiazolidin-4-ones have been synthesized by the reaction of dialkylacetylenedicarboxylates with thiosemicarbazones.The reaction was performed in the presence of 10 mol% of triphenylphosphine and tetrabutylammonium bromide as a phase transfer catalyst in water as a green solvent.All the synthesized compounds were characterized by their physical and spectral data.