Author/Authors :
GOHARI, AHMAD REZA tehran university of medical sciences tums - Medicinal Plant Research Center, تهران, ايران , HADJIAKHOONDI, ABBAS tehran university of medical sciences tums - Medicinal PlantResearch Center and Pharmaceutical Sciences Research Center - Department of Pharmacognosy, تهران, ايران , SADAT-EBRAHIMI, ESMAEIL tehran university of medical sciences tums - Faculty of Pharmacy,Medicinal Plant Research Center and Pharmaceutical Sciences Research Center - Department ofMedicinal Chemistry, تهران, ايران , SAEIDNIA, SOODABEH tehran university of medical sciences tums - Medicinal Plant Research Center, تهران, ايران , SHAFIEE, ABBAS tehran university of medical sciences tums - Faculty of Pharmacy, Medicinal Plant Research Center andPharmaceutical Sciences Research Center - Department ofMedicinal Chemistry, تهران, ايران
Abstract :
From the aerial parts of Satureja macrantha C. A. Mey, one monoterpene (1), two triterpenoids (2,3) andone sesquiterpene (4) were isolated. Their structures were determined to be thymol (1), oleanolic acid (2),ursolic acid (3) and caryophyllene oxide (4), by using 1H and 13C-NMR, FTIR and EIMS spectra. Brineshrimp cytotoxicity effects of the crude extracts and isolated compounds were examined. Among themcompounds 1 (612 μM), 2 (17 μM) and 3 (29 μM) were effective against Artemia salina larva.
Keywords :
Satureja macrantha , Artemia salina , Thymol , Caryophyllene oxide , Ursolic acid
