Author/Authors :
Yassa, N. tehran university of medical sciences tums - Faculty of Pharmacy - Department of Pharmacognosy, Medicinal Plant Research Center, تهران, ايران , Saeidnia, S. tehran university of medical sciences tums - Faculty of Pharmacy and Medicinal Plant Research Center - Department of Pharmacognosy, تهران, ايران , Pirouzi, R. islamic azad university - Faculty of Pharmacy, ايران , Akbaripour, M. tehran university of medical sciences tums - Faculty of Pharmacy and Medicinal Plant Research Center - Department of Pharmacognosy, تهران, ايران , Shafiee, A. tehran university of medical sciences tums - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Department of Medicinal Chemistry, تهران, ايران
Abstract :
From MeOH extract of aerial parts of Achillea millefolium L. collected from Golestan province of Iran, three glycosylated phenolic compounds, luteolin 7-O-glucoside, apigenin 7-O-glucoside and caffeic acid glucoside were isolated and identified by spectroscopic analyses. Immunological properties of different fractions of plant extract were studied on humoral immune system of BALB/c mice by Microhaemagglutination test. Among these fractions only two fractions at 125 mg kg-1 and 61.5 mg kg-1 showed a significant decrease in the anti- SRBC titer of mice (P 0.05). The immunological properties of the latter fractions may be due to glycosylated derivatives of caffeic acid.
Keywords :
Achillea millefolium , Asteraceae , Flavonoids , Humoral Immune System
