Title of article :
Inhibition of growth of Leishmania donovani promastigotes by newly synthesized 1,3,4-thiadiazole analogs
Author/Authors :
Al-Qahtani, Ahmed King Faisal Specialist Hospital and Research Centre - Molecular Virology and Infectious Diseases Section, Department of Biological and Medical Research, Riyadh , Siddiqui, Yunus M. King Faisal Specialist Hospital and Research Centre - Molecular Virology and Infectious Diseases Section, Department of Biological and Medical Research, Riyadh , Bekhit, Adnan A. University of Alexandria - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Egypt , El-Sayed, Ola A. University of Alexandria - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Egypt , Aboul-Enein, Hassan Y. National Research Centre - Pharmaceutical and Drug Industries Research Division - Pharmaceutical and Medicinal Chemistry Department, Egypt , Al-Ahdal, Mohammed N. King Faisal Specialist Hospital and Research Centre - Molecular Virology and Infectious Diseases Section, Department of Biological and Medical Research, Saudi Arabia , Al-Ahdal, Mohammed N. King Faisal Specialist Hospital and Research Centre - Department of Pathology and Laboratory Medicine, Riyadh
Abstract :
Leishmania donovani, the causative agent of visceral leishmaniasis, is transmitted by sand flies and replicates intracellularly in their mammalian host cells. The emergence of drug-resistant strains has hampered efforts to control the spread of the disease worldwide. Forty-four 1,3,4- thiadiazole derivatives and related compounds were tested in vitro for possible anti-leishmanial activity against the promastigotes of L. donovani. Micromolar concentrations of these agents were used to study the inhibition of multiplication of L. donovani promastigotes. Seven compounds were identified with potential antigrowth agents of the parasite. Compound 4a was the most active at 50 lM followed by compound 3a. These compounds could prove useful as a future alternative for the control of visceral leishmaniasis
Keywords :
Thiadiazoles , Leishmania donovani , Antiparasite , Antileishmanial
