Title of article :
Synthesis and anti-histaminic activity of some novel pyrimidines
Author/Authors :
Rahaman, Sk.A. KVSR Siddhartha College of Pharmaceutical Sciences - Department of Pharmaceutical Chemistry, India , Pasad, Y. Rajendra Andhra University - University College of Pharmaceutical Sciences, India , Kumar, Phani Andhra University - University College of Pharmaceutical Sciences, India , Kumar, Bharath Andhra University - University College of Pharmaceutical Sciences, India
Abstract :
Novel pyrimidines were prepared by the condensation of chalcones of 40-piperazine acetophenone with guanidine HCl. The structures of the synthesized compounds RP 1–5 were assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy. These compounds were also screened for anti-histaminic activity. The recorded percentage of histamine inhibition showed a significant anti-histaminic activity when compared to the reference anti-histaminic drug mepiramine
Keywords :
Pyrimidine , Chalcone , Anti , histaminic activity
Journal title :
Saudi Pharmaceutical Journal(SPJ)
Journal title :
Saudi Pharmaceutical Journal(SPJ)
