Title of article :
Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues
Author/Authors :
Hassan, Ghada S. King Saud University - College of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia , El-Emam, Ali A. King Saud University - College of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia , Gad, Laila M. King Abdulaziz University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Saudi Arabia , Barghash, Alaa Eldin M. Mansoura University - College of Pharmacy - Department of Medicinal Chemistry, Egypt
Abstract :
A new series of 1-adamantyl derivatives was designed, synthesized and evaluated for their antimicrobial and antiviral activities. Representative derivatives of the newly synthesized compounds were tested. Ampicillin, clotimazole and the antiviral antibiotic aphidicolin were used as positive controls. Compound 18 proved to be the most active member of this series as antimicrobial against Staphylococcus aureus and Candida albicans and as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.02 mg/ml while compound 19 proved to be the most active member of this series as antiviral with IC50 value of 0.21 mg/ml and CD50 value of 0.01 mg/ml.
Keywords :
Synthesis , 1 , Adamantyl , Antimicrobial testing , Antiviral screening
Journal title :
Saudi Pharmaceutical Journal(SPJ)
Journal title :
Saudi Pharmaceutical Journal(SPJ)
