Author/Authors :
Gahtori, Prashant Dibrugarh University - Department of Pharmaceutical Sciences, India , Ghosh, Surajit Kumar Dibrugarh University - Department of Pharmaceutical Sciences, India , Singh, Brijesh Dibrugarh University - Department of Pharmaceutical Sciences, India , Singh, Udaya Pratap Sam Higginbottom Institute of Agriculture Technology Sciences (Formerly-AllahabadAgricultural Institute - Department of Pharmaceutical Sciences, India , Bhat, Hans Raj Sam Higginbottom Institute of Agriculture Technology Sciences (Formerly-AllahabadAgricultural Institute - Department of Pharmaceutical Sciences, India , Uppal, Archana Shri Guru Ram Rai Institute of Technology Science - Department of Pharmaceutical Sciences, India
Abstract :
A series of hybrid novel chloro (1a–9a) and dichloro (10b–18b) phenylthiazolyl-s-triazine were synthesized and subsequently subjected to their antibacterial activity against three gram positive viz. Lactobacillus casei (NCIM-2651); Bacillus cereus (NCIM-2458); Staphylococcus aureus (NCIM-2120) and three gram negative viz Salmonella typhimurium (NCIM-2501); Escherichia coli (NCIM-2065); Klebsiella aerogenes (NCIM-2098). The SAR studies around the lead compound revealed that introduction of electron withdrawing groups and amino (–NH–) and mercapto (–S–) linker bridge seemed more promising towards antibacterial activity. Moreover, the virtual Molinspiration screenings are in compliance with Ghose’s rule.
Keywords :
s , Triazines , Amines , Linker bridge , MIC , Broth dilution assay
