Author/Authors :
Maheshwari, Rahul G.S. IPS Academy - College of Pharmacy, India , Tekade, Rakesh K. Process Development Laboratory (An R D extension), India , Sharma, Piyoosh A. Sri Aurobindo Institute of Pharmacy - Department of Pharmaceutical Chemistry, India , Darwhekar, Gajanan IPS Academy - College of Pharmacy, India , Tyagi, Abhishek Indian Council of Medical Research - Institute of Cytology and Preventive Oncology, India , Patel, Rakesh P. Ganpat University - S K Patel College of Pharmaceutical Education Research, India , Jain, Dinesh K. IPS Academy - College of Pharmacy, India
Abstract :
The objective of work was to formulate, evaluate and compare the transdermal potential of novel vesicular nanocarriers: ethosomes and ultradeformable liposomes, containing clotrimazole (CLT), an anti-fungal bioactive. The ethosomal formulation (ET4) and ultradeformable liposomal (UL) formulation (TT3) showed highest entrapment 68.73 ± 1.4% and 55.51 ± 1.7%, optimal nanometric size range 132 ± 9.5 nm and 121 ± 9.7 nm, and smallest polydispersity index 0.027 ± 0.011 and 0.067 ± 0.009, respectively. The formulation ET4 provided enhanced transdermal flux 56.25 ± 5.49 μg/cm2/h and decreased the lag time of 0.9 h in comparison to TT3 formulation (50.16 ± 3.84 μg/cm2/h; 1.0 h). Skin interaction and FT-IR studies revealed greater penetration enhancing effect of ET4 than TT3 formulation. ET4 formulation also had the highest zone of inhibition (34.6 ± 0.57 mm), in contrast to TT3 formulation (29.6 ± 0.57 mm) and marketed cream formulation (19.0 ± 1.00 mm) against candidal species. Results suggested ethosomes to be the most proficient carrier system for dermal and transdermal delivery of clotrimazole
Keywords :
Anticandidal efficiency , Atomic force microscopy , Ethosomes , Nanocarriers , Ultradeformable liposomes
