Author/Authors :
Pradhan, Shrabani Raja N.L. Khan Women’s College - Research Unit - Department of Nutrition, Microbiology and Human Physiology, India , Mandal, Shreya Raja N.L. Khan Women’s College - Research Unit - Department of Nutrition, Microbiology and Human Physiology, India , Roy, Suchismita Raja N.L. Khan Women’s College - Research Unit - Department of Nutrition, Microbiology and Human Physiology, India , Mandal, Arpita Raja N.L. Khan Women’s College - Research Unit - Department of Nutrition, Microbiology and Human Physiology, India , Das, Koushik Raja N. L. Khan Women’s College - Research Unit - Department of Nutrition, Microbiology and Human Physiology, India , Nandi, Dilip K. Raja N.L. Khan Women’s College - Research Unit - Department of Nutrition, Microbiology and Human Physiology, India
Abstract :
Uremia means excess nitrogenous waste products in the blood their toxic effects. An acute acetaminophen (paracetamol, N-acetyl p-aminophenol; APAP) overdose may result into potentially fatal hepatic and renal necrosis in humans and experimental animals. The aims of this present study were to investigate the protective effect of alpha-lipoic acid (ALA) on oxidative stress uremia on male albino rats induced by acetaminophen. The study was performed by 24 albino male Wister strain rats which were randomly divided into four groups: Group I, control – receives normal food and water, Groups II, III IV receive acetaminophen interperitoneally at the dose of 500 mg/kg/day for 10 days, from 11th day Groups III IV were treated with ALA at the dose of 5 mg 10 mg/100 g/day for 15 days, respectively. After 25 days of treatment, it was observed that there was a significant increase in plasma urea, creatinine, sodium and malondialdehyde (MDA) levels (p 0.05) but a significant decrease in super oxide dismutase (SOD) catalase activity potassium level in uremic group is compared with control group there was a significant increase in SOD catalase (p 0.05) a significant decrease in serum urea, creatinine Na and MDA (p 0.05) in Group III Group IV is compared with Group II significant changes were observed in high ALA dose group. In conclusion it was observed that the ALA has nephroprotective activities by biochemical observations against acetaminophen induced uremic rats
Keywords :
Uremia , Acetaminophen , Oxidative stress , Alpha , lipoic acid (ALA)
