Comparative Assessment of the Effect of Diminazene Aceturate and Imidocarb Dipropionate on Haematology and Serum Biochemical Parameters of Apparently Healthy Nigerian Dogs

DIMINAZENE aceturate (DIAC) and Imidocarb diproprionate (IMD) are drugs of choice in the management of some heamoprotozoan diseases. In this study we evaluated the comparative effects of the two drugs on the haematology and serum biochemical parameters of Nigerian local dogs. Fifteen (15) apparently healthy Nigerian dogs were used in this study. Dogs were randomly divided into three equal groups. Group A received no treatment and served as control. Groups B received intramuscular injection 3.5mg/kg DIAC and group C received 5.5 mg/kg of IMD via intramuscular injection. Blood samples were collected 24 hours after the administration of the drugs. through the cephalic vein from each dog for haematology and serum analysis. Packed cell volume (PCV), white blood cell (WBC), neutrophil, lymphocytes were counted. Serum aspartate aminotransferase (AST), alanine amino transferase (ALT), calcium, and chloride were measured. The overall results revealed that neither DIAC nor IMD treated groups caused any significant deviations from the untreated controls in all the above parameters assayed. In conclusion, both drugs are safe to use for treating heamoprotozoan diseases in the same dosage.