Title of article :
Spectrophotometric Method for Determination of Trimetazidine in Formulation Using Chloranil as Chromogenic Agent
Author/Authors :
Ganesh, Mani Hanseo University - Department of Chemical Engineering, South Korea , Hemalatha, Pushparaj Hanseo University - Department of Chemical Engineering, South Korea , Kumar, Arthanari Sravana Anna University of Technology - Department of Nano Technology, Biotechnology centre, India , Mei, Peng Mei Hanseo University - Department of Chemical Engineering, South Korea , Jang, Hyun Tae Hanseo University - Department of Chemical Engineering, South Korea
Abstract :
A new, simple, selective and more reproducible spectrophotometric method for the determination of trimetazidine (TMZ), a piperizinyl antianginal has been developed and validated. This method wasbased on the formation of a blue colored chromogen between trimetazidine and chloranil acetaldehyde reagent in DMSO. The chromogen exhibit maximum absorbance at 627 nm with molar absorptivity of 5.205 x 10^4 lit mol^-1 cm^-1 in methanol. Beer’s law was found to be obeyed in the concentration range of 30 - 65 μg mL^-1 with linear regression of 0.9984, while the percentage recovery and the limit of detection 98.81-99.91%, 5.5 μg mL^-1 respectively. From the percentage recovery and placebo studies it was concluded that there was no interference of additives during the estimation. This shows the suitability of this method for the routine analysis of the trimetazidine in tablet formulation.
Keywords :
Trimetazidine , Chloranil , Spectrophotometric , Formulations
Journal title :
eurasian journal of analytical chemistry
Journal title :
eurasian journal of analytical chemistry
