Title of article :
Absence of Toxicity of Strobilanthes crispaJuice in Acute Oral Toxicity Study in Sprague Dawley Rats
Author/Authors :
Norfarizan-Hanoon, N.A. Universiti Sains Malaysia - School of Health Sciences, Malaysia , Asmah, R. Universiti Putra Malaysia - Faculty of Medicine and Health Science - Department of Nutrition and Dietetic, Malaysia , Rokiah, M.Y. Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Nutrition and Dietetics, Malaysia , Fauziah, O. Universiti Putra Malaysia - Faculty of Medicine and Health Science - Department of Human Anatomy, Malaysia , Faridah, H. Universiti Putra Malaysia - Malaysian Agricultural Research and Development Institute, Malaysia
Abstract :
This study evaluated four different doses of Strobilanthes crispa juice (700, 2100, 3500 and 4900 mg kg-1 of body weight) administered orally to normal female and male Sprague dawley rats on possible changes in various physical, behaviour, morphology and biochemical parameter. The rats were treated with a single dose of juice and observed for 14 days. No significant toxicity was observed with respect to clinical parameters and organ morphology. In addition, no significant changes were observed in the level of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, creatinine and albumin. The S. crispus juice was found to be safe at the maximum dose used in this study (4900 mg kg-1 of body weight)
Keywords :
Acute toxicity , clinical parameters , organ morphology , S. crispus juice
