Gastric cardia adenocarcinoma pathway analysis

Gastric cardia adenocarcinoma (GCA) is one of the few malignancies with unexplained reasons, which have increased abruptly in developed countries. The purpose of this study was to determine the pathways in GCA to identify a new biomarker. Therefore, by comparing gene expression in GCA group with normal control identified important pathways. Gene expression data were extracted from the beforehand investigations then differentially expressed genes utilized in the DAVID program to explore and find related pathways. Our findings contain 367 gene names. Out of these 367 proteins, 199 were found to be exclusively expressed in GCA; whereas 168 proteins were detected down-regulated or silenced. The GCA associated diseases are based on the differently expressed genes made up of disease pathways related to colorectal cancer, small cell lung cancer, breast cancer and H. pylori infection stomach cancer. KEGG pathways related to GCA contained cell cycle, p53 signaling pathway, DNA replication, toll-like receptor signaling pathway and some other diseases. The GO-discovered categories also demonstrated most biological process and molecular function related to cancer. Up until now, there is no report to introduce influential biomarkers in GCA. Therefore, the deregulated genes identified in GCA patterns might be helpful for diagnosis, prognosis and therapies for gastric cancer but validation of these biomarkers is necessary. © 2013 RIGLD.