Author/Authors :
abdolsamadi, Hamidreza hamadan university of medical sciences, ايران , eini, Peiman hamadan university of medical sciences, ايران , ronasi, Negin hamadan university of medical sciences, ايران , kaboli, Alireza hamadan university of medical sciences, ايران , hajilooei, Mehrdad hamadan university of medical sciences, ايران , moghimbeigi, Abbas hamadan university of medical sciences, ايران , davoudi, Poorandokht hamadan university of medical sciences, ايران , ahmadimotemayel, Fatemeh hamadan university of medical sciences, ايران , Mohaghegh Shalmani, Hamid shahid beheshti university of medical sciences, تهران, ايران
Abstract :
Aim: The aim of this study was to determine the concentration of salivary Β2M as a marker of viral proliferation in HBS Ag+, HBV DNA PCR+ and Hbs Ag+ and HBV DNA PCR- subjects. Background: Beta-2 microglobulin (Β2M) is responsible for transmission of viral antigens such as Hepatitis B (HBV) on the surface of liver cells as part of an HLA complex. Patients and methods: In this case control study, 25 PCR+ and 2 PCR- patients were included. 5 mL of the saliva sample was obtained from all patients and salivary Β2M level was measured using nephelometer. The data was evaluated by the descriptive, chi-square and t-tests. Results: 72% of the PCR+ patients received medications and in contrast, 85.7% of the patients with PCR- did not take any medication (P lt;0.001). The average salivary concentration of Beta-2 microglobulin in the PCR+ group (5.28 ± 5.45 mg/deciliter) was more than PCR- group (1.51±0.77) and this difference was statistically significant (P=0.003). Conclusion: the salivary B2M level can be used as a marker of viral proliferation in patients with hepatitis B. © 2013 RIGLD.
Keywords :
Beta , 2 microglobulin , Hepatitis B , Saliva , Virus proliferation marker
