Author/Authors :
MD RODUAN, MOHD ROHAIZAD Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Pathology, Malaysia , MOHTARRUDIN, NORHAFIZAH Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Pathology, Malaysia , PEI PEI, CHONG Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Biomedical Sciences, Malaysia , OSMAN, MALINA Universiti Putra Malaysia - Faculty of Medicine and Health Sciences - Department of Medical Microbiology Parasitology, Malaysia , DUSA, NORAINI MOHD Hospital Kuala Lumpur - Department of Pathology, Malaysia
Abstract :
Inflammation plays an important role to the process of prostate carcinogenesis by increasing the rate of cell proliferation, which contributes to an aggressive tumour phenotype. Cyclooxygenase-2 (COX-2) has been found overexpressed in various types of cancer cells including prostate. The aim of this study was to investigate the COX-2 expressions in different types of human prostate tissues. Paraffin-embedded prostate tissues from 263 samples were examined for the expression of COX-2 marker by immunohistochemistry method. COX-2 was found highly expressed in prostate adenocarcinoma (p=0.001) as compared to benign and normal tissues. The score of COX-2 expressions in most of normal prostate was weak 49 (77.8%), while only 16 (16%) of BPH showed strong expression. 56 cases (56%) prostate cancer showed strong COX-2 expression. Prostate cancer cases showed significant differences in staining patterns as tumour grade increased. In addition, COX-2 expression was significantly correlated with Gleason score in cancerous tissues. This study suggests that COX-2 overexpression is associated with prostate cancer and higher grade tumour.
Keywords :
Cyclooxygenase , 2 (COX , 2) , immunohistochemistry , inflammations , overexpression , prostate adenocarcinoma
