Author/Authors :
shirkani, afshin bushehr university of medical sciences - school of medicine - allergy and clinical immunology department, Bushehr, Iran , mansouri, atena mashhad university of medical sciences - student research committee, nanotechnology research center, school of pharmacy, Mashhad, Iran , abbaszadegan, mohammad reza mashhad university of medical sciences - immunology research center, avicenna research institute, medical genetics research center, faculty of medicine - division of human genetics, Mashhad, Iran , faridhosseini, reza mashhad university of medical sciences - allergy research center, school of medicine, Mashhad, Iran , jabbari azad, farahzad mashhad university of medical sciences - allergy research center, school of medicine, Mashhad, Iran , gholamin, mehran mashhad university of medical sciences - school of paramedical sciences, immunology research center, avicenna research institute - department of laboratory sciences, division of human genetics, Mashhad, Iran
Abstract :
Background: The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA3 single nucleotide polymorphisms and AR in an Iranian population was identified. Methods: This case-control study was performed on 86 patients with AR and 86 healthy subjects. This study aimed to evaluate a potential association between two GATA3 SNPs, rs1269486 and rs2229360, and AR. Blood samples were collected and DNA was extracted for the evaluation of these SNPs by RFLP-PCR. Results: A statistically-significant association was found between rs1269486 and AR (P 0.001). The frequencies of the A and GA genotypes were less in patients than in controls. The frequencies of the G allele and the GG genotype were greater in patients than in controls (P 0.001). Conclusions: SNP rs1269486 of GATA3 was associated with AR and sensitivity to aeroallergens in our population. Because of the significance of this gene in AR, studying the association between GATA3 polymorphisms and AR is recommended for other populations.
Keywords :
Allergic rhinitis , GATA3 , Genetic , SNP
