Title of article :
Predictive Factors for Ultrasonographic Grading of Nonalcoholic Fatty Liver Disease
Author/Authors :
Ghamar-Chehreh, Mohammad Ebrahim baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Disease, ايران , Khedmat, Hossein baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Disease, ايران , Karbasi, Ashraf baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Diseases, ايران , Amini, Mohsen baqiyatallah university of medical sciences - Baqyiatallah Research Center for Gastroenterology and Liver Disease, ايران , Taheri, Saeed baqiyatallah university of medical sciences - Medical Research Group, ايران
From page :
1
To page :
4
Abstract :
Background: There are several studies in the literature investigating factors which can induce non-alcoholic fatty liver disease (NAFLD) in different populations. However, the existing literature lacks powerful studies addressing the factors which may predict the severity of NAFLD. Objectives: In the current study, we aimed to evaluate factors independently associated with liver echogenicity in an Iranian NAFLD patient population. Patients and Methods: A total of 393 patients attending as outpatients at the Hepatol- ogy Clinic of Baqiyatallah University of Medical Sciences were entered into this analysis. Univariate and multivariable linear regression models were performed to evaluate the effects of the study variables on the NAFLD grade, defined by ultrasound hepatic echo- genicity. Results: Univariate linear analyses revealed a significant relationship between; the ultrasonographic grading of NAFLD and body weight (P 0.001), abdominal girth (P = 0.007), pelvic girth (P = 0.032), fasting blood glucose (FBS) (P = 0.005), serum insulin (P = 0.035), hemoglobin A1c (HbA1c) (P = 0.012), triglycerides (P = 0.049), aspartate aminotransferase (AST) (P = 0.015), alanin aminotransferase (ALT) (P = 0.026), and homeostasis model as- sessment (HOMA) (P = 0.002). Multivariable linear regression models left only; HbA1C (P = 0.011, β = 0.133), body weight (P = 0.001; β = 0.176) and serum triglyceride (P = 0.034; β = 0.112) as factors independently associated with liver echogenicity. Conclusions: Diabetic patients can reduce liver damage of NAFLD with control of their HbA1C through the lower ranges. Hypertriglyceridemia and body weight are the other implicated factors, which worsen hepatic echogenicity in the NAFLD patient population. We recommend future prospective studies and clinical trials to confirm our findings.
Keywords :
Ultrasonography , Non , Alcoholic Fatty Liver Disease
Journal title :
Hepatitis Monthly
Journal title :
Hepatitis Monthly
Record number :
2557701
Link To Document :
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