Author/Authors :
Abbasinazari, Mohammad shahid beheshti university of medical sciences - Department of Clinical Pharmacy, تهران, ايران , Behnava, Bita baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Diseases, ايران , Panahi, Yunes baqiyatallah university of medical sciences - Chemical Injuries Research Center, ايران , Hajhossein Talasaz, Azita tehran university of medical sciences tums - School of Pharmacy - Department of Clinical Pharmacy, تهران, ايران , Salimi, Shima baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Diseases, ايران , Keshvari, Maryam Iranian Blood Transfusion Organization Research Centre, ايران , Mehrnoush, Leila baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Diseases, ايران , Karimi Elizee, Pegah Middle East Liver Diseases Center, ايران , Gholami Fesharaki, Mohammad baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Diseases, ايران , Asgharinia, Mansour shahid beheshti university of medical sciences - Department of Clinical Pharmacy, تهران, ايران , Alavian, Moayed baqiyatallah university of medical sciences - Baqiyatallah Research Center for Gastroenterology and Liver Diseases, ايران , Alavian, Moayed Iranian Blood Transfusion Organization Research Centre, ايران
Abstract :
Background: Zinc deficiency has been reported frequently in hepatitis C patients in the literature. Furthermore, a decrease in zinc level has been shown in beta thalassemia major as well. Iranians consume a large amount of phytate in their regimens which can bind with zinc and decrease its gastrointestinal absorption.Objectives: This study was designed to determine plasma zinc level in an Iranian sample with the diagnosis of hepatitis C with or without concomitant beta thalassemia major.Patients and Methods: Between April 2011 and April 2012, plasma zinc level was determined via atomic absorption method, in 130 hepatitis C patients with or without beta thalassemia major in a known referral center of hepatic diseases in Tehran, Iran.Results: Mean ± standard deviation (SD) of plasma zinc levels was determined as 0.78 ± 0.22 mg/L. Also zinc level was 0.76 ± 0.19 mg/L and 0.80 ± 0.24 mg/L in thalassemic and non thalassemic patients, respectively. T-test analysis showed that there is no significant difference between these two groups regarding plasma zinc level (P = 0.235).Conclusions: It is concluded that zinc level of studied patients is less than which is reported in normal Iranian population. Moreover, there is not a significant difference in plasma zinc levels between thalassemic and non thalassemic patients and it seems to be a common problem in both ones. Addition of zinc supplement may be recommended in both groups in order to optimize the nutritional support and probably improve the treatment response.
Keywords :
Zinc , Beta , Thalassemia , Hepatitis C , Iran
