Author/Authors :
Potthoff, Andrej Hannover Medical School - Department of Gastroenterology, Germany , Hahn, Anreas Hannover Medical School - Department of Biometrics, Germany , Kubicka, Stefan Hannover Medical School - Department of Gastroenterology, Germany , Schneider, Andrea Hannover Medical School - Department of Gastroenterology, Germany , Wedemeyer, Jochen Klinikum Robert Koch Gehrden - Department of Internal Medicine, Germany , Klempnauer, Juergen Hannover Medical School - Department of Visceral and Transplant Surgery, Germany , Manns, Michael Hannover Medical School - Department of Gastroenterology, Germany , Gebel, Michael Hannover Medical School - Department of Gastroenterology, Germany , Boozari, Bita Hannover Medical School - Department of Gastroenterology, Germany
Abstract :
Background: Biliary complications are significant source of morbidity after liver transplantation (LT). Cholangiography is the gold standard for diagnosis and specification of biliary complications. Objectives: Detailed analyses of ultrasound (US) as a safe imaging method in this regard are still lacking. Therefore we analyzed systematically the diagnostic value of US in these patients. Patients and Methods: Retrospectively, 128 liver graft recipients and their clinical data were analyzed. All patients had a standardized US examination. The findings of US were compared to cholangiographic results in 42 patients. Following statistical analyses were performed: descriptive statistics, sensitivity, specificity, positive and negative predictive values (PPV, NPV). Results: 42 patients had 54 different biliary complications (Anastomotic stenosis (AS) n = 33, ischemic type biliary lesions (ITBL) n = 18 and leakage n = 3). US detected n = 22/42 (52%) patients with biliary complications. The sensitivity, specificity, PPV and NPV of US were: 61%, 100%, 100%, 79% (95CI, 36-86%) for ITBL and 24%, 100, 100%, 31% (95CI, 9-46 %) for AS, respectively Conclusions: US examination had no false positive rate. Therefore, it may be helpful as a first screening modality. But for the direct diagnosis of the biliary complication US is not sensitive enough.
