Author/Authors :
Sharafi, Heidar Iran Hepatitis Network, ايران , Sharafi, Heidar Middle East Liver Disease (MELD) Center, ايران , Sharafi, Heidar Armin Pathobiology Laboratory, ايران , Alavian, Moayed Iran Hepatitis Network, ايران , Alavian, Moayed Middle East Liver Disease (MELD) Center, ايران , Behnava, Bita Iran Hepatitis Network, ايران , Behnava, Bita Middle East Liver Disease (MELD) Center, ايران , Pouryasin, Ali Iran Hepatitis Network, ايران , Pouryasin, Ali Armin Pathobiology Laboratory, ايران , Pouryasin, Ali islamic azad university - Department of Genetics, ايران , Keshvari, Maryam Iran Hepatitis Network, ايران , Keshvari, Maryam Middle East Liver Disease (MELD) Cente, ايران , Keshvari, Maryam High Institute for Research and Education in Transfusion Medicine - Blood Transfusion Research Center, ايران
Abstract :
Background: About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in host genetics affect the outcome of HCV infection. Single nucleotide polymorphisms (SNPs) of the Interferon lambda (IFNL) genes were associated with spontaneous and treatment-induced clearance of HCV infection. Objectives: The aim of this study was to evaluate the association between the IFNL4 rs12979860 SNP and spontaneous clearance of HCV infection in Iranian population. Materials and Methods: A case-control study was designed on 91 cases with spontaneous HCV infection clearance and 259 patients with persistent HCV infection as the control group. The rs12979860 SNP was assessed as the most common IFNL polymorphism by PCR-RFLP method. Results: Distribution of rs12979860 CC genotype in the spontaneous clearance group was around two folds of its distribution in chronic hepatitis C group (P 0.001, OR = 4.09, 95% CI = 2.44-6.86). Conclusions: The rs12979860 SNP was observed as a strong host genetic factor associated with spontaneous clearance of hepatitis C infection.
