Author/Authors :
Keyvani, Hossein iran university of medical sciences - Department of Virology, ايران , Sohrabi, Masoudreza iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Zamani, Farhad iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Poustchi, Hossein tehran university of medical sciences tums - Liver and Pancreatobiliary Disease Research Center, Digestive Disease Research institute (DDRI), تهران, ايران , Ashrafi, Hossein Kingston University - Department of Pathology, UK , Saeedian, Fatemeh iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Mooadi, Mansooreh iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Motamed, Nima iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Ajdarkosh, Hossein iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Khonsari, Mahmoodreza iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Hemmasi, Gholamreza iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Ameli, Mitra iran university of medical sciences - Gastrointestinal and Liver Diseases Research Center (GILDRC), ايران , Kabir, Ali shahid beheshti university of medical sciences - School of Publich Health - Department of Epidemiology, تهران, ايران , Khodadost, Mahmoud
Abstract :
Background: Viral hepatitis is a major health problem worldwide. Change in transmission patterns of hepatitis B makes it necessary to re-evaluate its prevalence and risk factors. Objectives: We aimed to determine the prevalence of HBV infection and its related risk factors in Amol city, Northern Iran. Patients and Methods: As a population based study, a cluster sampling approach was used and 6146 individuals from the general population of urban and rural areas of Amol, Iran, from both genders and different ages were enrolled. Inclusion criteria were willingness to participate in the study, being a lifelong resident in Amol city or its surrounding areas with Iranian nationality. Ten milliliters (10 mL) of blood was taken from each study subject and checked regarding hepatitis B markers including HbsAg, HBsAb and HBcAb using a third generation ELISA. The prevalence of HBV infections and its potential risk factors were recorded. Results: The prevalence of HBsAg, HBsAb and HBcAb were estimated as 0.9%, 30.7% and 10.5%, respectively. The mean age of all participants was 43.9 (95% CI: 43.4, 44.3) in females and 55.6 in (n = 3472) males. In our study, there was a significant association between family history of hepatitis, rural residency and presence of HBsAg. There was also a positive correlation between HBcAb and family history of hepatitis, history of other types of hepatic diseases, history of tattooing, traditional phlebotomy, male gender and age. In backward logistic regression, a significant association was found between history of hepatitis in first-degree family members (OR = 13.35; 95% CI: 6.26, 28.47) and place of residence (OR = 2.32; 95% CI: 1.27, 4.22) with presence of HBsAg. There was also a positive correlation between history of hepatitis among first-degree family members (OR = 2.49; 95% CI: 1.52, 4.08), history of tattooing (OR = 2.13; 95% CI: 1.33, 3.42), history of previous hepatitis (OR = 1.87; 95% CI: 1.06, 3.28), male sex (OR = 1.36; 95% CI: 1.12, 1.66) and age (OR = 1.03; 95% CI: 1.03, 1.04) with presence of HBcAb. Conclusions: The prevalence of hepatitis B in Amol City and its surrounding areas was about one percent, a lower rate than other reports from Iran.
Keywords :
Hepatitis B Virus , Infection , HBsAg , Prevalence , Epidemiology
