Reactive Oxygen Species Production of Neutrophils in Patients With Acute Promyelocytic Leukemia During Treatment With All-Trans Retinoic Acid

We measured N-formyl-methionyl-luecyl-phenylalanine-induced reactive oxygen species production by neutrophils from three patients with acute promyelocytic leukemia during treatment with all-trans retinoic acid using a luminol-enhanced chemiluminescence assay, The maximum level of reactive oxygen species production during all-trans retinoic acid treatment was 58.8 ± 2.3 x 10(POWER 4) (mean ± SEM) counted photons per second (cps),which was significantly higher (p < 0.0001) than that of neutrophils from healthy volunteers (13.3 ± 2.3 x 10(POWER 4) cps). Am. J. Hematol.